Ocular Neovascularization

Ocular Neovascularization Caused by Herpes

Ferrochelatase is a therapeutic target for ocular neovascularization

Ocular neovascularization underlies major blinding eye diseases such as "wet" age-related macular degeneration (AMD). Despite the successes of treatments targeting the vascular endothelial growth factor (VEGF) pathway, resistant and refractory patient populations necessitate discovery of new therapeutic targets. Using a forward chemical genetic approach, we identified the heme synthesis enzyme ...

Ocular Sarcoidosis Limited to Retinal Vascular Ischemia and Neovascularization

A 59-year-old Caucasian male experienced progressive vision loss secondary to retinal vascular ischemia and neovascularization. At no time did he present with uveitis or vasculitis, and his serology tests were all negative. He was soon after diagnosed with sarcoidosis by hilar lymph node lung biopsy. Our patient demonstrates an atypical presentation of ocular sarcoidosis, manifesting solely as ...

Verteporfin photodynamic therapy of choroidal neovascularization secondary to ocular toxoplasmosis.

had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Financial Disclosure: None. Funding/Support: This study was supported in part by an unrestricted grant from Research to Prevent Blindness, New York, NY, and grant NEI EY02698 to Paul Kaufman, MD, from the National Institutes of Health, Bethesda, Md. Acknowle...

Endocan Blockade Suppresses Experimental Ocular Neovascularization in Mice.

Purpose Ocular neovascularization (NV) is a pathologic process characterized by the proliferation and infiltration of various types of cells such as RPE, glial, and endothelial cells, which interact with proangiogenic factors and inflammatory cytokines. Endocan is known to be enriched in retinal endothelial tip cells under hypoxia, but the effect of endocan on ocular NV progression is largely u...